Microwave Assisted Synthesis, Characterization of New Heterocyclic Compounds and Evaluation as Anti Breast Cancer

Abstract

      A number of new heterocyclic compounds derived from vanillin dimer chalcones were prepared by Claisen–Schmidt condensation using a microwave as a heat source and a base medium as a catalyst. The structures and suggestion mechanisms of reaction of the new products were attributed to elementary and spectroscopic analysis. Additionally, the in vitro anticancer compounds activity of (Z1, Z2, Z3, Z7, Z8 and Z9) and all of them showed high inhibition efficiency except (Z2) were evaluated with a human breast cancer cell line (Cal51), and compared with standard anticancer drugs, according standard MTT assay. The synthesized heterocyclic compounds were characterized based on their chemical properties and spectroscopic data (FTIR, ¹H NMR, ¹³C MNR and CHN-S).